Effect of Common Genetic Variants Associated with Type 2 Diabetes and Glycemic Traits on α- and β-cell Function and Insulin Action in Man
نویسندگان
چکیده
From the Department of Clinical Sciences, Diabetes and Endocrinology, Lund University, Malmö, Sweden, Lund University Diabetes Centre, Malmö, Sweden, Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical and Sciences, University of Copenhagen, Copenhagen, Denmark, Folkhälsan Research Centre, Helsinki, Finland, Department of Social Services and Health Care, Jakobstad, Finland, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland, Finnish Institute of Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland, Steno Diabetes Center A/S, Gentofte, Denmark
منابع مشابه
Effects of Common Genetic Variants Associated With Type 2 Diabetes and Glycemic Traits on α- and β-Cell Function and Insulin Action in Humans
Although meta-analyses of genome-wide association studies have identified >60 single nucleotide polymorphisms (SNPs) associated with type 2 diabetes and/or glycemic traits, there is little information on whether these variants also affect α-cell function. The aim of the current study was to evaluate the effects of glycemia-associated genetic loci on islet function in vivo and in vitro. We studi...
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